世间万物无时无刻不暴露在变幻莫测的环境当中，和我们的健康和疾病息息相关。无论是空气，水，土壤，食物里的微生物和化合物，还是在我们体内和体表共生的大量微生物以及其代谢物，都在宏观或者微观角度影响着我们生活健康的方方面面（对其他物种亦然）。然而，由于种种原因，我们却对这些复杂的物理、化学、生物环境因素缺乏全面系统的了解，对这些环境因素在时间空间上的变化更是知之甚少，而对这些暴露如何影响人体及其他物种健康也缺乏相关研究。最后，结合环境暴露组和疾病健康多组学的研究方法，也为各类复杂人类疾病的机理探索提供了新的可能。
我们研究的目的就是为了改变这个现状。
实验室目前主要研究方向为：
宏观和个体环境暴露组（exposome) 的生物和化学组分的多样性、以及其在时间空间上的动态变化 (spatiotemporal dynamics)；
个体环境暴露组（personalized exposome) 相关的监测技术和可穿戴设备的开发和运用；
泛环境微生物组及微生物从宏观到微观水平的进化动态，种群遗传学;
环境暴露组以及微生物组（microbiome) 与人类疾病健康和环境的相互作用过程及其机理；
环境暴露组和微生物组相关的分子实验技术和计算分析方法的开发以及运用；
泛环境微生物组深度数据挖掘；
多组学及机器学习在精准医学研究的应用；
如果你有感兴趣的基于环境暴露组或者微生物组的研究课题，也非常欢迎与我探讨。
We are continuously exposing to a dynamic and vast collection of environmental exposures everyday, all of which have the potential to directly or indirectly impact our health or even daily activities. Specifically, biological and chemical exposures from air, water, soil, food, and the commensal microbial communities living on and inside us, along with their metabolites, can directly influence our health and disease status. Some of these exposures have been widely recognized, such as the consequences of long-term smoking and drinking. However, due to various reasons, the complexity of these environmental exposures is so far largely understudied, and a systematic view of the spatial-temporal dynamics of these exposures have yet to be achieved. The consequeces of these emerging exposures on human health are still unknown.
Our mission is to change the status quo. Current research directions:
The spatial-temporal dynamics of the biological and chemical exposome;
The evolutionary dynamics pan-environmental microbiome;
The role of exposome and microbiome in human health;
Development of experimental and computational methods for microbiome and exposome research;
Development of new wearable devices for exposome monitoring;
Deep-mining microbiome data;
Application of multi-omics and machine learning in precision medicine;
Link to video：https://www.seeker.com/videos/health/how-your-invisible-exposome-cloud-could-be-messing-with-your-health
Link to reference：https://www.sciencedirect.com/science/article/pii/S0092867418311218
https://doi.org/10.1002/imt2.50
我们长期欢迎对以上方向感兴趣的博士加入实验室共同探索
We welcome students and postdocs who share the same interests to explore with us!
Email：jiang_chao@zju.edu.cn