2019年后已发表工作:
11. Shao Y#, Shu X#, Lu Y#, Zhu W, Li R, Fu H, Li C, Sun W, Li Z, Zhang Y, Cao X, Ye X, Ajiboye E, Zhao B, Zhang L, Wu H, Feng XH, Yang B*, Lu H*. A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation. Nat Cell Biol. 2024 Jan;26(1):86-99. doi: 10.1038/s41556-023-01309-3.
10. Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H*, Chen FX*. R-loop-dependent promoter-proximal termination ensures genome stability. Nature. 2023 Aug 9. doi: 10.1038/s41586-023-06515-5.
9. Li, C.#, Li, Z.#, Wu, Z., & Lu, H* (2023). Phase separation in gene transcription control. Acta biochimica et biophysica Sinica, 10.3724/abbs.2023099. https://doi.org/10.3724/abbs.2023099
8. Lu, H.*, Yang, M., & Q. Zhou* (2022). Reprogramming transcription after DNA damage: recognition, response, repair, and restart. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2022.11.010
7. Fu H.#, Liu R.#, Jia Z.#, Li R., Zhu F., Zhu W., Shao Y., Jin Y., Xue Y., Huang J., Luo K., X. Gao*, H. Lu*, & Q. Zhou* (2022). Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage. Nat Cell Biol. 24(4), 513–525.
6. Li, C. and H. Lu* (2021). Rolling the RBP snowballs. Nat Chem Biol. https://doi.org/10.1038/s41589-021-00902-7
5. Zhu, H., H. Fu, T. Cui, L. Ning, H. Shao, Y. Guo, Y. Ke, J. Zheng, H. Lin, X. Wu, G. Liu, J. He, X. Han, W. Li, X. Zhao, H. Lu, D. Wang, K. Hu and X. Shen (2021). RNAPhaSep: a resource of RNAs undergoing phase separation. Nucleic Acids Res.
4. Zhang, H., X. Cao, M. Tang, G. Zhong, Y. Si, H. Li, F. Zhu, Q. Liao, L. Li, J. Zhao, J. Feng, S. Li, C. Wang, M. Kaulich, F. Wang, L. Chen, L. Li, Z. Xia, T. Liang, H. Lu, X. H. Feng and B. Zhao (2021). A subcellular map of the human kinome. Elife 10.
3. Wang, S., T. Dai, Z. Qin, T. Pan, F. Chu, L. Lou, L. Zhang, B. Yang, H. Huang, H. Lu and F. Zhou (2021). Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity. Nat Cell Biol 23(7): 718-732.
2. Wang, B., L. Zhang, T. Dai, Z. Qin, H. Lu, L. Zhang and F. Zhou (2021). Liquid-liquid phase separation in human health and diseases. Signal Transduct Target Ther 6(1): 290.
1. Shao, H., Q. Zhu, H. Lu, A. Chang, C. Gao, Q. Zhou and K. Luo (2020). HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer. Mol Biol Cell 31(17): 1867-1878.
2019年回国以前发表工作:
1. Huasong Lu, Dan Yu, Anders Hansen, Sourav Ganguly, Rongdiao Liu, Alec Heckert, Xavier Darzacq, and Qiang Zhou. Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II. Nature (2018)
2. Huasong Lu#, Yuhua Xue#, Guoying Yu, Carolina Arias, Julie Lin, Susan Fong, Michel Faure, Ben Weisburd, Xiaodan Ji, Alexandre Mercier, James Sutton, Kunxin Luo, Zhenhai Gao, Qiang Zhou.Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. Elife (2015)
3. Huasong Lu, Zichong Li, Wei Zhang, Ursula Schulze-Gahmen, Yuhua Xue and Qiang Zhou.Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription. Nucleic Acids Res (2015)
4. Huasong Lu, Zichong Li, Yuhua Xue, Ursula Schulze-Gahmen, Jeffrey R. Johnson, Nevan J. Krogan, Tom Alber, and Qiang Zhou. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. Proc Natl Acad Sci U S A (2014)
5. Huasong Lu#, Zichong Li#, Yuhua Xue, and Qiang Zhou. Viral-Host Interactions That Control HIV-1 Transcriptional Elongation. Chem. Rev(2013)
6. Zichong Li, Huasong Lu and Qiang Zhou. A minor subset of Super Elongation Complexes plays a predominant role in reversing HIV-1 latency. Mol. Cell. Biol (2016)
7.Xiaodan Ji, Huasong Lu, Qiang Zhou, and Kunxin Luo. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. Elife (2014)
8.Ursula Schulze-Gahmen, Huasong Lu, Qiang Zhou, Tom Alber. AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife (2014)
9. Ursula Schulze-Gahmen, Ignacia Echeverria, Goran Stjepanovic, Yun Bai, Huasong Lu, Dina Schneidman-Duhovny, Jennifer A Doudna, Qiang Zhou, Andrej Sali and James H Hurley. Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife (2016)
10. Cong Wang, Shuiyuan Yang, Huasong Lu, Hongchao You, Man Ni, Wenjun Shan, Ting Lin, Xiang Gao, Haifeng Chen, Qiang Zhou, Yuhua Xue. A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP. PLoS ONE (2015)
11. Seemay Chou, Heather Upton, Katherine Bao, Ursula Schulze-Gahmen, Avi J. Samelson, Nanhai He, Anna Nowak, Huasong Lu, Nevan J. Kroganb, Qiang Zhou, and Tom Alber. HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. Proc Natl Acad Sci U S A (2013)
12.Huasong Lu, Lingwei Ruan, Xun Xu. An immediate-early protein of white spot syndrome virus modulates the phosphorylation of focal adhesion kinase of shrimp. Virology (2011)
13. Defu Yao, Lingwei Ruan, Huasong Lu, Hong Shi and Xun Xu. Shrimp STAT was hijacked by white spot syndrome virus immediate-early protein IE1 involved in modulation of viral genes. Fish Shellfish Immunol (2016)