到浙大后的工作

1.      Ding W, Yu W, Chen Y, Lao L, Fang Y, Fang C, Zhao H, Yang B, Lin S*. “Rare codon recoding for efficient noncanonical amino acid incorporation in mammalian cells”, Science, 2024, 384, 1134-1142.

2.      Xie X*, Lin S*. “Targeting and manipulating tryptophan interactions on proteins”, ACS Chem. Biol., 2024, 18, 1211-1213. (Invited In Focus article)

3.      Zhu Y, Ding W, Chen Y, Shan Y, Liu C, Fan X*, Lin S*, Chen PR*. “Genetically encoded bioorthogonal tryptophan decaging in living cells”, Nat. Chem.,2024,16, 533-542.

4.      Ding W, Liu C, Chen Y, Gu J, Fang C, Hu L, Zhang L, Yuan Y, Feng XH, Lin S*. “Computational design and genetic incorporation of lipidation mimics in living cells”, Nat. Chem. Biol., 2024, 20, 42-51.

5.      Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y*, He C*, Lin S*. “O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins”, Nat. Cell Biol.,2023, 25, 1676-1690.

6.      Ding W, Zhao H, Chen Y, Lin S*. “New strategies for probing the biological functions of protein PTMs in mammalian cells with genetic code expansion”, Acc. Chem. Res., 2023, 56, 2827-2837.

7.      Zhao H, Tang L, Fang Y, Liu C, Ding W, Zang S, Chen Y, Xu W, Yuan Y, Fang D, Lin S*. “Manipulating cation-π interactions of reader proteins in living cells with genetic code expansion”, J. Am. Chem. Soc., 2023, 145, 16406-16416.

8.      Dai T, Zhang L, Ran Y, Zhang M, Yang B, Lu H, Lin S*, Zhang L*, Zhou F*. “DeSUMOylation by SENP1 inhibits LLPS of MAVS and antagonizes IRF3 activation in innate antiviral immunity”, Nat. Struct. Mol. Biol., 2023, 30, 785-799.

9.      Chen PR, Lin S, Li JP. Chapter 15: Genetic Code Expansion, in Advanced Chemical Biology: Chemical Dissection and Reprogramming of Biological Systems; Editors: Hang, H. C., Pratt, M. R., Prescher, J. A., Wiley-VCH, Weinheim, Germany, 2023, pp. 359-386.

10.   Zang J, Chen Y, Liu C, Hu L, Zhao H, Ding W, Yuan Y, Lin S*. “Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W”, Nat. Struct. Mol. Biol., 2023, 30, 62-71.

11.   Zang J, Chen Y, Liu C, Lin S*. “Probing the role of aurora kinase A threonylation with site-specific lysine threonylation”, ACS Chem. Biol., 2023, 18, 674-678. (Invited article for: ACS Chemical Biology Young Investigators Special Issue)

12.   Zhao H, Liu C, Ding W, Tang L, Fang Y, Chen Y, Hu L, Yuan Y, Fang D, Lin S*. “Manipulating cation-π interactions with genetically encoded tryptophan derivatives”, J. Am. Chem. Soc., 2022, 144, 6742-6748.

13.   Zhao H, Ding W, Zang J, Yang Y, Liu C, Hu L, Chen Y, Liu G, Fang Y, Yuan Y, Lin S*. “Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction”, Nat. Commun., 2021, 12, 7039.

14.   Ding W, Zhao H, Chen Y, Zhang B, Yang Y, Zang J, Wu J, Lin S*.“Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion”, Nat. Commun., 2020, 11, 3154.

15.   Zang J, Chen Y, Zhu W, Lin S*.“Chemoselective methionine bioconjugation on a polypeptide, protein, and proteome”, Biochemistry., 2020, 59, 132-138. (Invited review article for Future of Biochemistry: The Asia-Pacific Issue)

16.   Zhu X, Su Q, Xie H, Song L, Yang F, Zhang D, Wang B, Lin S, Huang J, Wu M, Liu T. “SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition”, Nat. Chem. Biol., 2023, 19, 585-595.

17.   Qin Z, Fang X, Sun W, Ma Z, Dai T, Wang S, Zong Z, Huang H, Ru H, Lu H, Yang B, Lin S, Zhou F, Zhang L. “Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity”, Nat. Immunol., 2022, 23, 1193-1207.

18.   Zhang Z, Fang X, Wu X, Ling L, Chu F, Li J, Wang S, Zang J, Zhang B, Ye S, Zhang L, Yang B, Lin S, Huang H, Wang A, Zhou F. “Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity”, Mol. Cell., 2020, 79, 304-319.

19.   Liu X, Xiao W, Zhang Y, Wiley SE, Zuo T, Zheng Y, Chen N, Chen L, Wang X, Zheng Y, Huang L, Lin S, Murphy AN, Dixon JE, Xu P, Guo X. “Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function”, Proc. Natl. Acad. Sci. U S A., 2020, 117, 328-336.

20.   Zhang M, Liang C, Chen Q, Yan H, Xu J, Zhao H, Yuan X, Liu J, Lin S, Lu W, Wang F. “Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability”, EMBO. J., 2020, 39, e101863.

回国前的工作

21.   Lin S#, Yang X#, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. “Redox-based reagents for chemoselective methionine bioconjugation”, Science, 2017, 355, 597-602.

22.   Lin S, Chen PR. “Fighting HIV at its own game”, Nat. Chem., 2014, 6, 566-568. News and Views

23.   Lin S, He D, Long T, Zhang S, Meng R, Chen PR. “Genetically encoded cleavable protein photo-cross-linker”, J. Am. Chem. Soc., 2014, 136, 11860-11863.

24.   Lin S#, Yan H#, Li L, Yang M, Peng B, Chen S, Li W, Chen PR, “Site-specific engineering of chemical functionalities on the surface of live hepatitis D virus”, Angew. Chem. Int. Ed., 2013, 52,13970-13974.

25.   Lin S, Zhang Z, Xu H, Li L, Chen S, Li J, Hao Z, Chen PR, “Site-specific incorporation of photocrosslinker and bioorthogonal amino acids into enteric bacterial pathogens”, J. Am. Chem. Soc., 2011, 133, 20581-20587.

26.   Zhang M#, Lin S#, Song X, Liu J, Fu Y, Ge X, Fu X, Chang Z, Chen PR, “A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance”, Nat. Chem. Biol., 2011, 7, 671-677. Cover

27.   Zheng H, Lin S, Chen PR. “Genetically encoded protein labeling and crosslinking in living Pseudomonas aeruginosa.”, Bioorg. Med. Chem., 2020, 28, 115545.

28.   Zheng H, Lin S, Chen PR. “Genetic code expansion in enteric bacterial pathogens.”, Methods. Mol. Biol., 2018, 1728, 113-126.

29.   Yang Y, Song H, He D, Zhang S, Dai S, Xie X, Lin S, Hao Z, Zheng H, Chen PR. “Genetically encoded releasable photo-cross-linking strategies for studying protein-protein interactions in living cells.”, Nat. Protoc., 2017, 12, 2147-2168.

30.   Zhang S, He D, Yang Y, Lin S, Zhang M, Dai S, Chen PR, “Comparative proteomics reveal distinct chaperone–client interactions in supporting bacterial acid resistance”, Proc. Natl. Acad. Sci. U S A., 2016, 113, 10872-10877.

31.   Yang Y, Song H, He D, Zhang S, Dai S, Lin S, Meng R, Wang C, Chen PR, “Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label”, Nat. Commun., 2016, 7, 12299.

32.   Cheng M, Zhang W, Yuan J, Luo W, Li N, Lin S, Yang Y, Fang X, Chen PR, “Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells”, Chem. Commun., 2014, 50, 14724-14727.

33.   Yang Y, Lin S, Lin W, Chen PR, “Ligand-assisted dual-site click labeling of EGFR on living cells”, Chembiochem., 2014, 15, 1738-1743.

34.   Li J, Yu J, Zhao J, Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen PR, “Palladium-triggered deprotection chemistry for protein activation in living cells”, Nat. Chem., 2014, 6, 352-361.

35.   Zhao J, Lin S, Huang Y, Zhao J, Chen PR, “Mechanism-based design of a photoactivatable firefly luciferase”, J. Am. Chem. Soc., 2013, 135, 7410-7413.

36.   Li J, Lin S, Wang J, Jia S, Yang M, Hao Z, Zhang X, Chen PR, “Ligand-free palladium-mediated site-specific protein labeling inside gram-negative bacterial pathogens”, J. Am. Chem. Soc., 2013, 135, 7330-7338.

37.   Yang M, Song Y, Zhang M, Lin S, Hao Z, Liang Y, Zhang D, Chen PR, “Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity”, Angew. Chem. Int. Ed., 2012, 52, 7674-7679.

38.   Hao Z, Song Y, Lin S, Yang M, Liang Y, Wang J, Chen PR, “A readily synthesized cyclic pyrrolysine analogue for site-specific protein “click” labeling”, Chem. Commun., 2011, 47, 4502-4504.

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