Hu ZS, Lu YK, Cao J, Lin LY, Chen X, Zhou ZY, Pu JQ, Chen G, Ma XJ, Deng Q, Jin Y, Jiang LL, Li YH, Li TW, Liu JZ, Zhu SY. N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling (2024).Science Advances 10: eadh9871.
Chen X, Lu YK , Wang LY, Ma XJ, Pu JQ, Lin LY, Deng Q, Li YH, Wang WY, Jin Y, Hu ZS, Zhou ZY, Chen G, Jiang LL, Wang H, Zhao XY , He XW, Fu JF, Russ H, Li W, Zhu SY. A fast chemical reprogramming system promotes cell identity transition through a diapause-like state (2023). Nature Cell Biology 25: 1146-1156.
Jin Y, Lu YK, Lin LY, Liu C, Ma XJ, Chen X, Zhou ZY, Hu ZS, Pu JQ, Chen G, Deng Q, Jiang LL, Li YH, Zhao YL, Wang H, Fu JF, Li W, Zhu SY. Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception (2023). PNAS 120 (21) e2215155120.
Ma XJ, Lu YK, Zhou ZY, Li Q, Chen X, Wang WY, Jin Y, Hu ZS, Chen G, Deng Q, Shang WN, Wang H, Fu HX, He XW, Feng XH, Zhu SY. Human expandable pancreatic progenitor–derived β cells ameliorate diabetes (2022). Science Advances 8: eabk1826.
Ma XJ, Cao J, Zhou ZY, Lu YK, Li Q, Jin Y, Chen G, Wang WY, Ge WY, Chen X, Hu ZS, Shu X, Deng Q, Pu JQ, Liang CZ, Fu JF, Liu JZ, Zhu SY. N6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis (2022). Nature Communications 13: 4148.
Wang WY, Ren SF, Lu YK, Chen X, Qu JJ, Ma XJ, Deng Q, Hu ZS, Jin Y, Zhou ZY, Ge WY, Zhu YB, Yang NN, Li Q, Pu JQ, Chen G, Ye CQ, Wang H, Zhao XY, Liu ZQ, Zhu SY. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production (2021). EMBO J 40: e106771.
Ma XJ, Chen X, Jin Y, Ge WY, Wang WY, Kong LH, Ji JF, Guo X, Huang J, Feng XH, Fu JF, Zhu SY. Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells (2018). Nature Communications 9: 1303.
Xu T, Stewart KM, Wang X, Liu K, Xie M, Kyu Ryu J, Li K, Ma TH, Wang HX, Ni L, Zhu SY, Cao N, Zhu DW, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S. Metabolic control of Th17 and induced Treg cell balance by an epigenetic mechanism (2017). Nature 548: 228-233.
Zhu SY, Russ H, Wang XJ, Zhang ML, Ma TH, Xu T, Tang SB, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts (2016). Nature Communications 7: 10080.
Zhang ML, Lin YH, Sun YJ, Zhu SY, Zheng JS, Liu K, Cao N, Li K, Huang YD, Ding S. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation (2016). Cell Stem Cell 18: 653-667.
Ma TH, Li J, Xu Y, Yu C, Xu T, Wang HX, Liu K, Cao N, Nie BM, Zhu SY, Xu SH, Li K, Wei WG, Guan KL, Ding S. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming (2015). Nature Cell Biology 17: 1379-1387.
Zhu SY, Wang HX, Ding S. Reprogramming fibroblasts toward cardiomyocytes, neural stem cells, and hepatocytes by cell activation and signaling directed lineage conversion (2015). Nature Protocols 10: 959-973.
Zhu SY, Rezvani M, Harbell J, Mattis A, Wolfe A, Benet L, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts (2014). Nature 508: 93-97.
Li K, Zhu SY, Russ H, Xu SH, Xu T, Zhang Y, Ma TH, Hebrok M, Ding S. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages (2014). Cell Stem Cell 14: 228–236.
Zhu SY, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang XJ, Zhang ML, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells (2014). Cell Research 24: 126–129.
Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu SY, Lipton S, Ding S. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions (2011). Cell Stem Cell 9: 113–118.
Kim J, Efe, JA, Zhu SY, Talantova M, Yuan X, Wang SF, Lipton S, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors (2011). PNAS 108: 7838–7843.
Zhu SY, Wei WG, Ding S. Chemical strategies for stem cell biology and regenerative medicine (2011). Annual Review of Biomedical Engineering 13: 73–90.
Zhu SY, Li WL, Zhou HY, Wei WG, Ambasudhan R, Lin TX, Kim J, Zhang K, Ding S. Reprogramming of human primary somatic cells by OCT4 and chemical compounds (2010). Cell Stem Cell 7: 651–55.
Zhou HY, Wu S, Joo J, Zhu SY, Han D, Lin TX, Trauger S, Bien G, Yao SY, Zhu Y, Siuzdak G, Scholer H, Duan LX, Ding S. Generation of induced pluripotent stem cells using recombinant proteins (2009). Cell Stem Cell 4: 381–384.
Li WL, Wei W, Zhu SY, Zhu JL, Shi Y, Lin TX, Hao E, Hayek A, Deng HK, Ding S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors (2009). Cell Stem Cell 4: 16–19.
Zhu SY, Yu XC, Wang XJ, Zhao R, Li Y, Fan RC, Shang Y, Du SY, Wang XF, Wu FQ, Xu YH, Zhang XY, Zhang DP. Two calcium-dependent protein kinases, CPK4 and CPK11, regulate abscisic acid signal transduction in Arabidopsis (2007). Plant Cell 19: 3019-3036.