报告题目：Adherent-Suspension Plasticity in CirculatingTumor Cells Reconstructs the etastatic Cascade
报告人：Hyun Woo Park 博士 
主持人：赵  斌 教授
时   间：2024年5月14日（周二）上午10:30
地   点：纳米楼457报告厅
报告人简介：

Dr. Hyun Woo Park is an associate professor in Dept. Of Biochemistry, Yonsei University, Translational Cancer Research Laboratory, And as a director of AST Metastasis Research Center. He completed his doctoral studies at Yonsei University and conducted his postdoctoral fellow training at UCSD (University of California. SanDiego)(PI: Kun-Liang Guan).

A specialized mechanism that reprograms anchorage dependency of solid tumor cells into circulating tumor cells (CTCs) during the metastatic cascade remains elusive.

Here, we discovered a biological phenomenon referred to as Adherent-to- Suspension Transition (AST) that reprograms adherent cells into suspension cells via aberrant induction of hematopoietic transcriptional regulators, IKZF1, NFE2, BTG2, and IRF8, which are hijacked by solid tumor cells to disseminate into CTCs. During dissemination, tumor microenvironment triggers the epigenetic alteration of AST factors in the invasive front of solid tumors to evoke spontaneous cell-matrix dissociation, acquire anoikis resistance, and bypass immune surveillance of CTCs, however, in the absence of lineage differentiation and EMT. By establishing the first cohort, which consists tissue- and liquid biopsy paired specimens of primary tumor, CTCs, and metastatic lesions in mouse models and de novo metastatic breast cancer patients, we uncovered how Adherent-Suspension Plasticity (ASP) dictates anchorage plasticity during the dissemination and colonization process within the metastatic cascade. Finally, we demonstrate therapeutic strategies that target AST factors to specifically abrogate CTC formation and suppress distant metastases.