报告题目：神经干细胞及脑发育调控机制研究
报告人：焦建伟 研究员 
主持人：赵   斌 教授
时   间：2023年10月16日（周一）上午10点
地   点：纳米楼457报告厅
报告人简介：

       焦建伟，中国科学院动物研究所研究员。担任生理学会干细胞生理专业委员会主委。获得国家杰青，万人领军人才，国家重点研发计划首席科学家，中科院百人计划。目前承担国家重点研发项目，基金委杰青、重点、创新群体项目，中科院先导专项等。主要从事神经干细胞和脑发育机制研究，探索脑发育疾病机理，为脑疾病诊治提供潜在靶点，为转化研究奠定理论基础。研究成果发表于国际期刊Cell Stem Cell, PNAS, Adv Sci, Sci Adv, Cell Res, Mol Psychiatry, Trends Cell Biol等70多篇。目前是生理学会理事，神经学会理事等，是杂志Fundamental Research, Cell Proliferation等编委。获得华夏医学科技奖，干细胞创新科学奖，妇幼健康科学技术奖等。

讲座摘要：

The mammalian brain contains millions of neurons and glial cells. Normal cerebral brain development plays an important role in controlling behavior, learning and cognition. During neurogenesis, neural progenitor cells (NPCs) proliferate and differentiate into neurons of cortical layers, which are precisely controlled by various intracellular and extracellular signaling pathways. NPCs of the brain are mainly PAX6-positive apical progenitor cells and TBR2-positive basal progenitor cells. Although more and more molecules are reported involved in the proliferation of progenitor cells, how neurogenesis is regulated by epigenetic factors during the embryonic development of the cerebral cortex remains largely to be investigated. Here, we found a series of epigenetic molecules and modifications are essential for the proliferation and self-renewal of neural stem cells.